​Key Publications on the Science Behind Renetx Programs:
NoGo Trap Program
​
Identification of a receptor mediating Nogo-66 inhibition of axonal regeneration.
Fournier AE, GrandPre T, Strittmatter SM. Nature. 2001 Jan 18;409(6818):341-6.
​​
Truncated soluble Nogo receptor binds Nogo-66 and blocks inhibition of axon growth by myelin.
Fournier AE, Gould GC, Liu BP, Strittmatter SM. J Neurosci. 2002 Oct 15;22(20):8876-83.

Nogo receptor antagonism promotes stroke recovery by enhancing axonal plasticity.
Lee JK, Kim JE, Sivula M, Strittmatter SM. Nogo receptor antagonism promotes stroke recovery by enhancing axonal plasticity. J Neurosci. 2004 Jul 7;24(27):6209-17.

Blockade of Nogo-66, myelin-associated gwww.ncbi.nlm.nih.gov/pubmed/15548666lycoprotein, and oligodendrocyte myelin glycoprotein by soluble Nogo-66 receptor promotes axonal sprouting and recovery after spinal injury.                                
Li S, Liu BP, Budel S, Li M, Ji B, Walus L, Li W, Jirik A, Rabacchi S, Choi E, Worley D, Sah DW, Pepinsky B, Lee D, Relton J, Strittmatter SM. J Neurosci. 2004 Nov 17;24(46):10511-20.

Delayed Nogo receptor therapy improves recovery from spinal cord contusion.
Wang X, Baughman KW, Basso DM, Strittmatter SM. Ann Neurol. 2006 Nov;60(5):540-9.

MAG and OMgp synergize with Nogo-A to restrict axonal growth and neurological recovery after spinal cord trauma.
Cafferty WB, Duffy P, Huebner E, Strittmatter SM. J Neurosci. 2010 May 19;30(20):6825-37.

Recovery from chronic spinal cord contusion after Nogo receptor intervention.
Xingxing Wang, Philip Duffy, Aaron W. McGee, Omar Hasan, Grahame Gould, Nathan Tu, Noam Y. Harel, Yiyun Huang, Richard E. Carson, David Weinzimmer, Jim Ropchan, Larry I. Benowitz, William B. J. Cafferty, and Stephen M. Strittmatter,  Ann. Neurol. 2011;70:805–821

Nogo limits neural plasticity and recovery from injury.
Schwab ME, Strittmatter SM.  Curr Opin Neurobiol. 2014 Aug;27:53-60.

Human NgR-Fc decoy protein via lumbar intrathecal bolus administration enhances recovery from rat spinal cord contusion.
Wang X, Yigitkanli K, Kim CY, Sekine-Komo T, Wirak D, Frieden E, Bhargav

Intravitreal delivery of human NgR-Fc decoy protein regenerates axons after optic nerve crush and protects ganglion cells in glaucoma models. 
Wang X, Lin J, Arzeno A, Choi JY, Boccio J, Frieden E, Bhargava A, Maynard G,  Tsai JC, Strittmatter SM.  Invest Ophthalmol Vis Sci. 2015 Feb 5;56(2):1357-66.